Fremantle's quest for a maiden AFL premiership is gathering steam after they knocked over the Brisbane Lions by 25 points at the Gabba.

The Dockers extended a club-record winning streak to 11, their 15.13 (103) to 10.18 (78) victory on Saturday leaving them a game clear on top of the ladder after 12 rounds.

Their only loss was to perennial contenders Geelong by 10 points in round one.

But the Lions' tilt at a second flag "three-peat" is well and truly on the skids, after yet another third-quarter fade-out when they gave up six goals.

Many of their best players - Lachie Neale, Hugh McCluggage and Josh Dunkley - were subdued.

They were blown away when the dominant Dockers slammed on five goals in 10 minutes that left the home crowd stunned.

It was crowned by a trademark goal on the run by "unicorn" ruckman Luke Jackson, following up his own centre-square work.

It gave the visitors a 40-point lead they would maintain at the final break, with the game as good as gone for the Lions.

The Lions pushed hard in the final term, kicking four goals to win the quarter, but Dockers forward Josh Treacy iced the result with his third major.

The Dockers were dominant in the air up forward, where Jye Amiss, Patrick Voss and Treacy bagged 11 goals between them.

Voss - a virtual decoy behind the talents of Treacy and Amiss - proved a massive handful with four, missing a couple of sitters along the way.

Amiss also kicked four, with Treacy pushing higher up the ground where his physicality terrorised the Lions.

At ground level, they were quicker, stronger and more aggressive, hunting the Lions into submission with a remarkably even team performance.

Stacked with elite talent in every part of the ground, their work rate made the reigning premiers of the past two years look ordinary.

They were also ultra-disciplined in their set-up behind the ball, with only Darcy Wilmot able to pick his way through the purple maze regularly.

Once again the Lions looked lost without their playmaker Dayne Zorko, sidelined for at least another month with a quad injury.

The loss of attacking half-back Keidean Coleman to a hamstring injury just before quarter-time added to the Lions' difficulties in defensive transition.

They had enough of the ball in their own half, going inside their attacking 50 59 times to 47, but were easily repelled by a well-organised Dockers defence.

The only sour note for the Dockers was a knee injury to defender Brennan Cox, which was not thought to be serious.